Evaluation of efficacy and safety of Acne-N-Pimple cream in acne vulgaris

Acne vulgaris is a common skin disorder and the available drugs have been shown to be associated with specific limitations. The present study was planned to evaluate the efficacy and safety of “Acne-N-Pimple Cream” in the management of acne vulgaris. This study was a prospective, open, non-comparative, phase III clinical trial and a total of 26 patients, who were diagnosed as suffering from acne vulgaris were included in the study. Children below 18 years of age, patients with pre-existing systemic disease necessitating long-term medication, genetic and endocrinal disorders, and those who refused to give informed consent were excluded from the study. Pregnant the lactating women were also excluded from the study. A baseline history was obtained, which included personal data, a description of symptoms and details of past medical history and thereafter all patients underwent a clinical examination and thorough skin examination. All the patients were advised to apply the “Acne-N-Pimple Cream” on the affected area, twice daily for a period of 6 weeks. All the patients were followed up for a period of 6 weeks. The predefined primary efficacy endpoints were reduction in number of blackheads and whiteheads, inflamed pustules and overall inflammation along with an increase in exfoliation, overall moisturizing and soothing effect, and healing without scar formation. The predefined secondary safety endpoints were incidence of adverse events and compliance to the drug treatment. This study observed significant reduction in the number of blackheads and whiteheads, in number of inflamed pustules and overall inflammation. Similarly there was enhanced exfoliation, moisturizing and soothing effect along-with significant improvement in healing without scar formation. There were no clinically significant shortand long-term adverse reactions, during the entire period of the study and excellent patient compliance to “Acne-NPimple Cream” was observed. The excellent results obtained might be due to the antioxidant, anti-inflammatory, antiandrogenic and antimicrobial properties of the ingredients. Therefore, it may be concluded that “Acne-N-Pimple Cream” is clinically effective and safe in the management of acne vulgaris. Introduction Acne vulgaris is a common skin disorder, affecting virtually all adolescents and adults at some time in their lives. Although the overall health is not impaired, acne is not a trivial disease, as it can produce cutaneous and emotional scars that last a lifetime. Numerous psychological problems stem from acne, some even resulting in decreased employability in adulthood. The etiology of acne is multifactorial and according to the severity of inflammation, acne is classified into purely comedonal (non-inflammatory acne), mildly papular, scarring papular and scarring nodular acne. Clinically, the peak incidence of acne is evident during the teen